Nitrogen and sulphur fertilization positively affected on crop yields and bioactive compounds (vitamin C, E1 and ß-carotene) content in cauliflower edible heads. Applying fertilization doses of 250 kg N.ha-1 and 60 kg S.ha-1 compared to the control improved cauliflower harvest by 15,2 t.ha-1. Increased fertilization doses of nitrogen and sulphur significantly increased vitamin C and ß-carotene content in the cauliflower. High significant difference in vitamin C level was found comparing the control variant and variant of nitrogen fertilization at the level of 200 kg N.ha-1. In percentage terms this is an increase in vitamin C level by 22,4%. Fertilization with increased doses of nitrogen and sulphur affected significantly the amount of ß-carotene compared to unfertilized variant. Increased doses of N and S did not respond adequately to vitamin E1 content in cauliflower.