The aim of the study was to determine the effect of immunostimulation of sows during the perinatal period (Biostymine,
Lydium-KLP) on physiological-production parameters of the sows: haematological and biochemical blood indices, colostrum and milk composition and fatty acid profile, physical (pH) and cytological (somatic cells count - SCC) parameters as well as results of reproduction and rearing of piglets. None effect of the examined immunostimulators on the most of the studied traits and indices was found. There were the changes in pH, energy level and composition
of milk. Additionally, the changes in fatty acid profile in milk fat were recorded; they consisted in significantly lower or higher participation of certain fatty acids in the samples, collected from the sows which received Biostymine, as compared to the group, receiving Lydium-KLP and/or groups which did not receive any additive.