The trends of the antioxidant drug “U-74389G” on potassium levels during hypoxia reoxygenation injury in rats

Abstract

Background: This experimental study examined the effect of the antioxidant drug “U-74389G”, on a rat model and particularly in an hypoxia – reoxygenation (HR) protocol. The beneficial effect or non-effectiveness of that molecule were studied biochemically using blood mean potassium levels.

Methods: 40 rats of mean weight 231.875 g were used in the study. Potassium levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D) with administration of the drug U-74389G in groups C and D.

Results were that U-74389G administration non significantly decreased the K⁺ levels by 2.14%+5.06% (p= 0.6730). Reoxygenation time non-significantly increased the K⁺ levels by 8.66%+4.85% (p= 0.0934). However, U-74389G administration and reoxygenation time together non-significantly increased the K⁺ levels by 2.07%+3.03% (P= 0.4853).

Conclusions are that U-74389G administration, reoxygenation time and their interaction have miscellaneous non significant short – term effects on potassium levels. Perhaps, a longer study time may reveal clearer and significant effects.