A young researcher’s guide to NME/Nm23/NDP Kinase

  • Maja Herak Bosnar Ruđer Bošković Institute
  • Martina Radić Ruđer Bošković Institute
  • Helena Ćetković Ruđer Bošković Institute


Nucleoside diphosphate kinases (NDPKs) catalyze the exchange of the terminal phosphate from trinucleotides to dinucleotides through a high-energy phosphohistidine intermedier. They are encoded by NME genes and have been found, with a few exceptions, in all living beings. Besides their well-known function as key regulators of the cellular nucleotide homeostasis, they have been appointed numerous additional biochemical and biological functions. The discovery of NME1/NDPK A as the first metastasis suppressor opened new avenues in cancer research. Although the precise role of NME genes/proteins in cancer dissemination is not yet revealed, it seems that further intensive research in this field may lead to new advances in cancer diagnosis and prognosis, as well as encourage new therapeutic strategies.

Author Biographies

Maja Herak Bosnar, Ruđer Bošković Institute
Division of Molecular Medicine, PhD, senior research associate
Martina Radić, Ruđer Bošković Institute
Division of Molecular Medicine, PhD student, mag. chem
Helena Ćetković, Ruđer Bošković Institute
Division of Molecular Biology, senior scientist