Skoči na glavni sadržaj

Arhiv za higijenu rada i toksikologiju, Vol. 62 No. 2, 2011.

Pregledni rad

https://doi.org/10.2478/10004-1254-62-2011-2107

Cholinesterases: Structure, Role, and Inhibition

Anita Bosak ; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Maja Katalinić orcid id orcid.org/0000-0001-7043-4291 ; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Zrinka Kovarik ; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska

Puni tekst: hrvatski pdf 304 Kb

str. 175-189

preuzimanja: 2.744

citiraj

Sažetak

Enzymes acetylcholinesterase (AChE; E.C. 3.1.1.7) and butyrylcholinesterase (BChE; E.C. 3.1.1.8) have intensively been investigated in biomedicine and toxicology due to important role in organisms. Even if structurally homologous, they differ in catalytic activity, specificity, for substrates, and selectivity in binding to many ligands. This paper compiles the results of research on cholinesterases and their interactions with ligands and inhibitors, and identifies amino acids of active sites involved in these interactions.

Ključne riječi

acetylcholinesterase; butyrylcholinesterase; inhibitors; selectivity; stereoselectivity

Hrčak ID:

69311

URI

https://hrcak.srce.hr/69311

Datum izdavanja:

17.6.2011.

Podaci na drugim jezicima: hrvatski

Posjeta: 5.291 *