Veterinarski arhiv, Vol. 73 No. 5, 2003.
Izvorni znanstveni članak
Iron supplementation therapy in the reversion of the haematological and immunological defects accompanying canine ancylostomosis.
Emmanuel Adeniyi Okewole
; Department of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria
Temidayo Olutayo Omobowale
; Department of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria
Matthew Oluremi Ayoola
; Mokola Veterinary Hospital, Ministry of Agriculture and Natural Resources, Ibadan, Nigeria
Sažetak
For the purpose of investigating the effects of iron supplementation on the therapy of experimental canine ancylostomosis, twenty 8 week old pups were rando mly divided into four equal groups A, B, C and D. Groups A, B and C were serially infected bi-weekly with infective Ancylostoma caninum (L3) larvae up to 98 days. Thereafter, Groups A and B were treated with pyrantel pamoate and dextrose saline infusion with or without iron dextran supplementation, respectively. Pups in Group C were left untreated as were the uninfected control pups in Group D. Clinical observations revealed a serial reversion of the distressing hookworm disease signs in only the two infected and treated Groups A and B, but not in the infected but untreated pups in Group C. Both the haematological, and immunological parameters were most elevated in the iron-treated pups in Group A, with high and positive correlation coefficient (r) of + 0.94, 0.83, 0.41 and 0.98 for the respective Groups A, B, C and D. Iron therapy was suggested as being responsible for the prompt haematological and immunological reversion observed in Group A pups through its facilitation of the haemoglobin synthesis and the iron dependent mitotic cell division processes.
Ključne riječi
ancylostomosis; haematology; immunology; iron supplementation; cell mitosis
Hrčak ID:
74461
URI
Datum izdavanja:
21.10.2003.
Posjeta: 1.521 *