Original scientific paper
Lifestyle Habits and the Risk of Head and Neck Cancer in Zagreb Region
Ariana Znaor
Mišo Virag
Tin Znaor
Spomenka Manojlović
Rajko Kušec
Abstract
In 2002, International Agency for Research on Cancer launched a multicentric case-control study of head and neck
cancer in 15 centres in 11 European countries, Croatia included. The Alcohol-related Cancers and Genetic Susceptibility
in Europe (ARCAGE) study database with approximately 2500 case-control pairs is currently the largest head and neck
cancer patients database in Europe. The aim of the present study was to estimate the risk of smoking and alcohol consumption
in head and neck cancer patients from Zagreb region recruited in scope of the ARCAGE study. The cases (45
males, 9 females) and the controls (37 males, 9 females) were recruited from University Hospital Dubrava and Merkur
University Hospital. A blood sample and a lifestyle questionnaire were collected from all study subjects. Data were analysed
by logistic regression analysis. The distribution of cases was: 43 oral, 9 pharyngeal and 2 laryngeal cancer cases.
Ever-smokers had a 4-fold higher cancer risk (adjusted OR 4.3 (CI 1.20–15.4)) compared to never-smokers. The adjusted
odds ratio for alcohol consumption more than once a week was 4.1 (CI 1.5–11.2). The results are in keeping with previously
published data from other countries.
Keywords
head and neck cancer; alcohol consumption; smoking
Hrčak ID:
75618
URI
Publication date:
30.12.2011.
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