Medicina, Vol. 48 No. 2, 2012.
Pregledni rad
Patohistological parameters and mitotic rate as a prognostic factor in primary melanoma of the skin
Ivana Budisavljević
; Zavod za patologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Emina Babarović
; Zavod za patologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Aleksandra Ljubačev
; Zavod za patologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Elvira Mustać
; Zavod za patologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Gordana Zamolo
; Zavod za patologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Sažetak
Malignant melanoma of the skin arises due to neoplastic transformation of melanocytes. Its behavior is characterized not so much by the local agressiveness of the primary tumor but rather by the pronounced and often very early tendency to produce lymphogenous and hematogenous metastases. In the last few years a better rate of survival has been observed as a result of early diagnosis. However, recent studies have been focused on determining reliable prognostic parameters which would allow more consistent and predictable course of disease with modification of therapy. The aim of this review was to determine the most important histopathological and clinical parameters which influence the prognosis and outcome of patients with malignant melanoma, and whether they can aid in the choice of the most suitable form of therapy. Depending of the histological type of tumor, patient gender, histological level of tumor progression according to Clark, tumor thickness according to Breslow and mitotic rate are considered to be the parameters of crucial importance for the prognosis of patients with malignant melanoma of the skin. The histological level of tumor progression according to Clark, tumor thickness according to Breslow and mitotic rate were proven to be independent, statistically significant parameters relevant for the outcome of patients with this disease.
Ključne riječi
malignant melanoma; mitotic rate; patohistological parameters
Hrčak ID:
84190
URI
Datum izdavanja:
4.6.2012.
Posjeta: 8.637 *