Veterinary Archives, Vol. 71 No. 4, 2001.
Original scientific paper
Influence of cadmium salts on gestation and foetuses in rabbits.
Tomislav Dobranić
; Department of Obstetrics and Reproduction, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Luka Štilinović
; Senior scientific adviser
Marijan Cergolj
; Department of Obstetrics and Reproduction, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Antun Tomašković
; Department of Obstetrics and Reproduction, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Darko Marković
; Pliva Inc., Research and Development – Pharmacology and Toxicology, Zagreb, Croatia
Abstract
Fifteen female rabbits of the Chinchilla bastard breed of reproductive age (7 months) were used in the study. The animals were naturally mated with 5 male rabbits at 3-day intervals. On day 10 of mating, pregnancy was established by abdominal palpation and ultrasonography in all 15 female rabbits. The rabbits were then divided into two experimental groups and one control group of 5 animals each. In group 1 spontaneous abortion occurred on day 20-22 of gestation. In group 2 abortion occurred on day 17-18 of gestation in three rabbits, whereas in two animals in which abortion did not occur, only a small part of necrotic placenta was found on section in the uterus. There were no teratogenic alterations of the aborted foetuses, whereas the placentae showed very pronounced changes in the form of necroses with abundant fibrin deposits and little structure preserved. In the control group of animals, pregnancies resulted in the delivery of healthy neonates, while the placental tissue showed normal structure. There were no macroscopic uterine lesions. In group 1 and 2 pathohistologic examination revealed decidual cell destruction and massive fibrin deposition in the decidual area.
Keywords
rabbit; cadmium chloride; pregnancy; placenta; pathohistologic lesions
Hrčak ID:
87904
URI
Publication date:
21.8.2001.
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