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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 66 No. 2, 2012.

Review article

CORRELATION BETWEEN PHOLCODINE AND PERIOPERATIVE ANAPHYLAXIS

JELENA DUMANČIĆ ; University of Zagreb, School of Medicine, Andrija Štampar School of Public Health, Department of Teaching Technology, Zagreb, Croatia
ASJA STIPIĆ MARKOVIĆ ; University of Zagreb, School of Medicine, Andrija Štampar School of Public Health, Department of Teaching Technology, Zagreb, Croatia

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Abstract

A large number of individuals experiencing anaphylactic reaction to neuromuscular blocking agents have not previously been in contact with them. The search for a substance inducing sensitization to muscle relaxants has led Norwegian and Swedish scientists
to pholcodine, a cough suppressant, which is widely used in Europe and worldwide. Ammonium ion is an epitope common to pholcodine and neuromuscular blocking agents and it is the basis of their cross-reactivity. Based on the results of published studies that pointed to a connection of the use of pholcodine and perioperative anaphylactic reaction, pholcodine was withdrawn from the Norwegian market and subsequent research revealed a reduction of anaphylactic reactions in that country. In its latest report, the European Medicines Agency made a decision not to withdraw pholcodine mixtures from the market but it urged further research with the aim to clarify the cross-reactivity between pholcodine and neuromuscular blocking agents.

Keywords

pholcodine; neuromuscular blocking agents; ammonium ion

Hrčak ID:

97235

URI

https://hrcak.srce.hr/97235

Publication date:

14.2.2013.

Article data in other languages: croatian

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