Pregledni rad

CORRELATION BETWEEN PHOLCODINE AND PERIOPERATIVE ANAPHYLAXIS

JELENA DUMANČIĆ ; Odjel za kliničku imunologiju, pulmologiju i reumatologiju, Klinika za unutarnje bolesti Medicinskog fakulteta u Zagrebu, Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska
ASJA STIPIĆ MARKOVIĆ ; Odjel za kliničku imunologiju, pulmologiju i reumatologiju, Klinika za unutarnje bolesti Medicinskog fakulteta u Zagrebu, Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska

Sažetak

A large number of individuals experiencing anaphylactic reaction to neuromuscular blocking agents have not previously been in contact with them. The search for a substance inducing sensitization to muscle relaxants has led Norwegian and Swedish scientists
to pholcodine, a cough suppressant, which is widely used in Europe and worldwide. Ammonium ion is an epitope common to pholcodine and neuromuscular blocking agents and it is the basis of their cross-reactivity. Based on the results of published studies that pointed to a connection of the use of pholcodine and perioperative anaphylactic reaction, pholcodine was withdrawn from the Norwegian market and subsequent research revealed a reduction of anaphylactic reactions in that country. In its latest report, the European Medicines Agency made a decision not to withdraw pholcodine mixtures from the market but it urged further research with the aim to clarify the cross-reactivity between pholcodine and neuromuscular blocking agents.

Ključne riječi

pholcodine; neuromuscular blocking agents; ammonium ion

Hrčak ID:

97235

URI

https://hrcak.srce.hr/97235

Datum izdavanja:

14.2.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.058 *