Kratko priopćenje
A ROLE OF WNT IN KIDNEY DEVELOPMENT AND FUNCTION
INES MESAR
; Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Klinika za unutarnje bolesti, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
PETAR KES
; Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Klinika za unutarnje bolesti, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
NIKOLINA BAŠIĆ JUKIĆ
; Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Klinika za unutarnje bolesti, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Sažetak
WNt 4 is a secreted glycoprotein that is critical for nephrogenesis during mesenchymal to epithelial transformation. Lately there are some experimental modles witch confirm a role of Wnt 4 during regeneration process in acute renal failure. on the other hand there are some evidence that Wnt 4 plays important role in renal fibrosis during experimental renal injury in rats that provide tubuloinerstitial fibrosis. When will Wnt 4 have a protective role or when will induce fibrosis still is not known and therefore futher studies will be necessary to gain a more precise understanding.
Ključne riječi
Wnt; kidney; tubulointerstitial fibrosis; acute renal failure
Hrčak ID:
99540
URI
Datum izdavanja:
3.4.2013.
Posjeta: 1.588 *