Original scientific paper

Sulfachloropyrazine disposition in Eimeria tenella infected chickens.

Aneliya M. Haritova ; Department of Pharmacology, Physiology of Animals and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Lubomir D. Lashev ; Department of Pharmacology, Physiology of Animals and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Vencislav C. Koinarski ; Department of Veterinary Microbiology, Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria

Abstract

The control of coccidiosis in chickens is undertaken mainly by administration of anticoccidial drugs. Sulfachloropyrazine-sodium is still used as an effective coccidiocidal compound to treat poultry with clinical signs of coccidiosis. However, its disposition after three days treatment in Eimeria tenella infected chickens has not been well studied. Pharmacokinetics of sulfachlorpyrazine-sodium was investigated in healthy chickens and chickens experimentally infected with E. tenella. Serum and tissue concentrations were determined by HPLC-PDA analysis. The values of absorption half-life (17.24 ± 3.50 h) and time for achievement of maximal serum concentrations Tmax (23.41 ± 3.78 h) of the sulfonamide were significantly higher in infected chickens. An accumulation index of 1.22 ± 0.13 was estimated and significantly higher serum concentrations were observed in E. tenella challenged animals. Significantly higher sulfachloropyrazine-sodium levels were found in the duodenum, caeca and the liver, which suggests that a longer withdrawn time could be expected in infected chickens after three days administration of the anticoccidial agent. The observed changes in sulfachloropyrazine disposition could be attributed to the alteration of the integrity of the intestines and decreased motility of the gastro-intestinal tract during the clinical coccidiosis.

Keywords

chicken; cocidiosis; Eimeria tenella; pharmacokinetics; sulfachloropyrazine

Hrčak ID:

99850

URI

https://hrcak.srce.hr/99850

Publication date:

28.3.2013.

Article data in other languages: croatian

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