Paediatria Croatica, Vol. 57 No. 2, 2013.
Sažetak sa skupa
ASSOCIATION BETWEEN INHERITED CYTOKINE POLYMORPHISMS AND CEREBRAL PALSY IN VERY PRETERM INFANTS
Helena Kapitanović Vidak
; Special Hospital for Children with Neurodevelopmental and Motor Difficulties, Goljak 2, Zagreb, Croatia
Sanja Kapitanović
; Laboratory for Personalized Medicine, Division of Molecular Medicine, Rudjer Bošković Institute, Bijenička c. 54, Zagreb, Croatia
Sažetak
Cerebral palsy is a nonprogressive motor disorder caused by white matter damage to the developing brain. Intrauterine infection/inflammation with activation of the cytokine network and elevated levels of proinflammatory cytokines has been identified as the most common cause of preterm delivery, white matter brain damage and cerebral palsy. The aim of our study was to evaluate the possible association between IL-6, IL-1β, IL-18, TNF-α, IL-8 and IL-10 cytokine polymorphisms and cerebral palsy in very preterm infants. An association was observed between TNF-α -1031 T/C high expression genotypes (TC and CC) (OR, 2.935; p=0.0004) as well as TNF-α -1031 C high expression allele (OR, 2.480; p=0.0003) and cerebral palsy. In addition, a statistically significant association was also found between three TNF-α-1031/-857/-308/-238 high expression genotype combinations (TC,CC,GG,GG; TC,CT,GG,GG and CC,CC,GG,GA) and cerebral palsy. An association was recorded between IL-1β -511/+3954 CT,CC genotype combination and cerebral palsy (OR, 4.000; p=0.027). In female infants, a statistically significant association was found between TNF-α -1031 T/C polymorphism as well as IL-1β -511 C/T and cerebral palsy. In addition, in female and male infants, a statistically significant association was observed between allele TNF-α -1031C and cerebral palsy. Our results suggest the role of TNF-α and IL-1β polymorphisms in genetic susceptibility to white matter damage and cerebral palsy in very preterm infants.
Ključne riječi
Hrčak ID:
105057
URI
Datum izdavanja:
25.6.2013.
Posjeta: 451 *