Izvorni znanstveni članak

Aflatoxicosis in rottweilers after eating moldy bread; clinicopathological features and effective tetrasulphate therapy.

Kerem Ural ; Department of Internal Medicine, Veterinary Faculty, Adnan Menderes University, Isikli, Aydin-Turkey
Bulent Ulutas ; Department of Internal Medicine, Veterinary Faculty, Adnan Menderes University, Isikli, Aydin-Turkey
Recai Tunca ; Department of Pathology, Veterinary Faculty, Adnan Menderes University, Isikli, Aydin-Turkey
Cavit Kum ; Department of Pharmacology, Veterinary Faculty, Adnan Menderes University, Isikli, Aydin-Turkey
Hamdi Avci ; Department of Pathology, Veterinary Faculty, Adnan Menderes University, Isikli, Aydin-Turkey
Murat Boyacioglu ; Department of Pharmacology, Veterinary Faculty, Adnan Menderes University, Isikli, Aydin-Turkey
Mehmet Gultekin ; Department of Internal Medicine, Veterinary Faculty, Adnan Menderes University, Isikli, Aydin-Turkey
Abidin Atasoy ; Department of Internal Medicine, Veterinary Faculty, Adnan Menderes University, Isikli, Aydin-Turkey

Sažetak

The purpose of this study was to describe the clinical, hematologic, gross, histopathologic and toxicologic findings and to report effective therapy application for aflatoxicosis in dogs, ascribed to the ingestion of moldy wet bread contaminated with aflatoxin. A prospective case series of 10 client-owned dogs from the same household developed toxicological signs after eating moldy bread treated with water that had been stored for an undetermined period, fully covered with a grey-green mold. All dogs exhibited vomiting followed by excessive salivation and hyperaesthesia. Among the surviving dogs (n = 7), three of them presented with diarrhea, depression, abdominal pain and two others showed icterus. One of the dead dogs was found on the initial referral. Two others were dead following initial diagnosis and prior to therapy application. The most common gross findings in the dogs were generalized icterus, mucosal or submucosal edema and petechial, to ecchymotic hemorrhages in the organs. Histopathological findings included focal necrotic areas extending from the periacinar to centroacinar regions in the liver, biliary hyperplasia, cholestasis and multifocal hemorrhages in the kidneys and lungs. Due to the sudden onset of clinical signs, the lack of exposure to other toxins, and the confirmed evidence of ingestion of moldy bread, the results of analysis of liver samples and the histopathological signs, the definitive diagnosis was mycotoxicosis. Therapeutic applications included tetrasulphate (an antidote) given orally, and supportive treatment with balanced electrolyte solutions, antiemetics and H2 receptor antagonist. All treated dogs (7/7) made a full recovery over 18-24 hours. The results of the present study reported here describe the clinicopathological features of aflatoxicosis in Rottweilers, suggesting that the use of tetrasulphate solution as an inexpensive and available therapy may have helped the survival of the dogs and might reverse the adverse health effects of mycotoxins.

Ključne riječi

aflatoxicosis; rottweiler; moldy bread; mycotoxicosis; tetrasulphate; therapy

Hrčak ID:

105385

URI

https://hrcak.srce.hr/105385

Datum izdavanja:

8.7.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.554 *