Kratko priopćenje

https://doi.org/10.2478/acph-2014-0017

In vivo human skin penetration of (–)-epigallocatechin-3-gallate from topical formulations

SANTO SCALIA ; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, 44121 Ferrara, Italy
VALENTINA TROTTA ; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, 44121 Ferrara, Italy
ANNA BIANCHI ; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, 44121 Ferrara, Italy

Sažetak

The aim of the study was to examine the effect of topical vehicles on the in vivo human stratum corneum penetration of the antioxidant and skin photoprotective agent (–)-epigallocatechin-3-gallate (EGCG). Model oil-in-water (o/w) emulsion and gel formulations containing 1 % (m/m) EGCG were prepared and subjected to photodegradation studies in order to select excipients that minimize the light instability of EGCG. The optimized emulsion and gel were applied to human volunteers and the EGCG percutaneous permeation was evaluated in vivo by the tape-stripping technique. No significant differences in the percentage of the applied EGCG dose diffused into the stratum corneum were observed between the o/w emulsion (36.1 ± 7.5 %) and gel (35.5 ± 8.1 %) preparations. However, the amount of EGCG permeated into the deeper region of human stratum corneum was significantly larger for the o/w emulsion compared to the gel. Therefore, the emulsion represents a suitable vehicle for topical delivery of EGCG.

Ključne riječi

(–)-epigallocatechin-3-gallate; topical application; in vivo human study; tape-stripping; emulsion; gel

Hrčak ID:

114601

URI

https://hrcak.srce.hr/114601

Datum izdavanja:

30.6.2014.

Posjeta: 3.086 *