Stručni rad

Pathophysiology of gout

Jasminka Milas-Ahić ; Klinički odjel za reumatologiju, alergologiju i kliničku imunologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Osijek, Osijek, Hrvatska
Višnja Prus ; Klinički odjel za reumatologiju, alergologiju i kliničku imunologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Osijek, Osijek, Hrvatska
Roberta Višević ; Klinički odjel za reumatologiju, alergologiju i kliničku imunologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Osijek, Osijek, Hrvatska

Sažetak

Hyperuricemia is rather often metabolic disorder in general population. It is multifactorial disorder influenced by purine rich diet, alcohol consumption, diuretics use and renal deterioration. In the presence of local urate superasturation and lower solubility, monosodium crystals are deposited in joints, kidneys and soft tissue leading to clinical manifestations, such as gout, tophaceus deposits, nephrolithiasis and uric nephropathy. Major advances in understanding the pathogenesis of hyperuricemia and gout have been made recently, including genetic studies of urate transporters in kidneys as well as innate immune inflammatory responses and cytokine production which will be discussed thoroughly in this paper.

Ključne riječi

patophysiology; gout; hyperuricemia

Hrčak ID:

124048

URI

https://hrcak.srce.hr/124048

Datum izdavanja:

25.10.2012.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.242 *