Reumatizam, Vol. 55 No. 1, 2008.
Stručni rad
Proposal for anti-TNFα therapy in adult patients with rheumatoid arthritis
Božidar Ćurković
; Klinika za reumatske bolesti i rehabilitaciju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Đurđica Babić-Naglić
; Klinika za reumatske bolesti i rehabilitaciju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Jadranka Morović-Vergles
; Zavod za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinička bolnica “Dubrava”, Zagreb, Hrvatska
Branimir Anić
; Zavod za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Simeon Grazio
; Klinika za reumatologiju, fizikalnu medicinu i rehabilitaciju, Klinička bolnica “Sestre milosrdnice”, Zagreb, Hrvatska
Sažetak
Rheumatoid arthritis is a chronic, inflammatory disease with the prevalence about 1 %. Rheumatoid arthritis is caracterized with synovitis, erosive changes of the joints, pain and functional deficit. Etiology is unknown. In the pathogenesis of rheumatoid arthritis the key role have proinflammatory citokines, particularly, tumour necrosis factor (TNFα). TNFα blockers have documented, fast and continuous efficacy with generally well accepted safety profile. Nowdays, TNFα antagonists are established drugs in early and late phase of rheumatoid arthritis. Prescription of TNFα antagonists is controlled, according local restrictions, regarding high costs of the therapy. On behalf of Croatian Society for Rheumatology we propose recommendations for the TNFα antagonist therapy in rheumatoid arthritis.
Ključne riječi
rheumatoid arthritis; TNF inhibitors; recommendations
Hrčak ID:
125317
URI
Datum izdavanja:
1.7.2008.
Posjeta: 1.145 *