Skoči na glavni sadržaj

Biochemia Medica, Vol. 24 No. 3, 2014.

Izvorni znanstveni članak

https://doi.org/10.11613/BM.2014.041

Ischemia modified albumin is an indicator of oxidative stress in multiple sclerosis

Ozgur Aydin ; Biochemistry Laboratory, Batman Maternity and Children’s Hospital, Batman, Turkey
Hamit Yasar Ellidag ; Central laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey
Esin Eren ; Biochemistry Laboratory, Antalya Public Health Center of Ministry of Health, Antalya, Turkey
Fatma Kurtulus ; Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey
Aylin Yaman ; Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey
Necat Yılmaz ; Central laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey

Puni tekst: engleski pdf 140 Kb

str. 383-389

preuzimanja: 616

citiraj

Sažetak

Introduction: Oligodendrocytes need iron in processes of energy generation and myelination. However, excessive levels of iron may exert iron induced oxidative stress and thus lead to tissue degeneration. Monitoring oxidative stress will be of paramount importance in follow-up of patients with many diseases including multiple sclerosis (MS). The aim of this study was to measure total anti-oxidative status (TAS), total oxidative status (TOS) and ischemia modified albumin (IMA) in stable relapse remitting MS (RRMS) patients.
Materials and methods: Thirty-five RRMS patients (15 males and 20 females; median age 42 (20-55) years) and thirty-five age-sex matched healthy controls (13 males and 22 females; median age 37 (21-60) years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald.
Results: IMA levels were significantly higher in RRMS patients (P < 0.001), while TAS and TOS did not show any significant difference between groups (P = 0.870 and P = 0.460, respectively).
Conclusions: Our results suggest IMA as a more efficient serum marker than TAS and TOS in detecting the oxidative stress in MS patients. Serum oxidative stress markers should be included in future study protocols besides clinical and radiological parameters

Ključne riječi

ischemia-modified albumin; multiple sclerosis; oxidative stress

Hrčak ID:

133562

URI

https://hrcak.srce.hr/133562

Datum izdavanja:

15.10.2014.

Posjeta: 1.838 *