Reumatizam, Vol. 61 No. 1, 2014.
Stručni rad
Henoch-Schönlein purpura with late-onset necrotising glomerulonephritis - a case report
Joško Mitrović
; Zavod za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti Medicinskog fakulteta Sveučilišta u Zagrebu, Klinička bolnica Dubrava, Zagreb, Hrvatska
Silva Pukšić
; Zavod za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti Medicinskog fakulteta Sveučilišta u Zagrebu, Klinička bolnica Dubrava, Zagreb, Hrvatska
Ivica Horvatić
; Zavod za nefrologiju i dijalizu, Klinika za unutarnje bolesti Medicinskog fakulteta Sveučilišta u Zagrebu, Klinička bolnica Dubrava, Zagreb, Hrvatska
Vesna Sredoja Tišma
; Kabinet za dermatovenerologiju, Klinička bolnica Dubrava, Zagreb, Hrvatska
Stela Bulimbašić
; Klinički zavod za patologiju, Klinička bolnica Dubrava, Zagreb, Hrvatska
Jadranka Morović-Vergles
; Zavod za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti Medicinskog fakulteta Sveučilišta u Zagrebu, Klinička bolnica Dubrava, Zagreb, Hrvatska
Sažetak
Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, while it is rare in adults. Typical clinical manifestations include palpable purpura without thrombocytopenia and/or coagulopathy, arthritis/arthralgia, abdominal pain, and/or renal involvement. In adulthood the disease tends to be more serious than in children, with renal manifestations developing over a period of several days to one month after initial symptoms.
In this article we present a 22-year-old female patient with cutaneous vasculitis and arthralgia, in whom renal disease developed 8 weeks after disease onset with microscopic hematuria and proteinuria in urinalysis. Renal biopsy subsequently performed revealed focal necrotising glomerulonephritis with IgA deposits. The patient was treated with high dose methylprednisolone followed by gradual tapering, which induced complete remission of the disease.
In conclusion, patients with HSP should be carefully monitored for systemic involvement, since serious renal disease can develop even as late as two months after disease onset.
Ključne riječi
Henoch-Schönlein purpura; vasculitis; glomerulonephritis
Hrčak ID:
137776
URI
Datum izdavanja:
30.9.2014.
Posjeta: 1.606 *