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GIANT CELL TUMOR OF BONE: RESULTS AND TREATMENT COMPLICATIONS

MARKO BERGOVEC ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Klinika za ortopediju, Zagreb,Hrvatska; Medicinsko sveučilište u Grazu, Klinika za ortopediju i ortopedsku kirurgiju, Graz, Austrija
MIKELA PETKOVIĆ ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Klinika za ortopediju, Zagreb,Hrvatska
MIROSLAV SMERDELJ ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Klinika za ortopediju, Zagreb,Hrvatska
SVEN SEIWERTH ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Zavod za patologiju, Zagreb, Hrvatska
LUKA BRKIĆ ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Zavod za patologiju, Zagreb, Hrvatska
ROBERT KOLUNDŽIĆ ; Klinički bolnički centar Sestre milosrdnice, Klinika za traumatologiju, Zagreb, Hrvatska
DUBRAVKO ORLIĆ ; Sveučilište u Zagrebu, Medicinski fakultet, Klinički bolnički centar Zagreb, Klinika za ortopediju, Zagreb,Hrvatska

Sažetak

Giant cell tumor of bone (GCT) is mostly benign, locally aggressive tumor with a high recurrence rate. GCT is treated primarily surgically,
and the approach is determined according to localization and local tumor behavior. The aim of this study was to analyze results and complications of surgical treatment of GCT at a tertiary orthopedic clinical center in Croatia. We analyzed all patients treated at University Department of Orthopedics, Zagreb University Hospital Center, during a 15-year period. From 1995 to 2009, 39 patients were surgically treated for GCT. Four patients were lost from follow up. In patients with low-grade GCT (n=12, 34%), we performed marginal-intralesional resection, whereas in patients with locally aggressive GCT we performed en bloc resection and reconstruction with tumor endoprosthesis or bone allograft (n=22, 63%). In one patient, the only treatment was tumor irradiation. Complications were evident in one-third of our patients. The most common complications were tumor recurrence (n=6, 50% of all complications) and deep infection (n=2, 17% of all complications). We performed amputation in two patients in whom osteosarcoma was revealed under GCT radiologic and histologic appearance. We performed 84 operations in 35 patients, not counting primary biopsy. In conclusion, treatment of GCT is complex, with a high incidence of tumor recurrence. Diagnosis and treatment are best provided through a multidisciplinary approach in highly specialized centers for orthopedic oncology.

Ključne riječi

giant cell tumor of bone; neoplasm; bone; orthopedics; surgery; recurrence

Hrčak ID:

142203

URI

https://hrcak.srce.hr/142203

Datum izdavanja:

22.7.2015.

Podaci na drugim jezicima: hrvatski

Posjeta: 10.814 *