Paediatria Croatica, Vol. 59 No. 1, 2015.
Stručni rad
https://doi.org/10.13112/PC.2015.6
Lavage with diluted surfactant as a treatment option for atelectasis in pediatric intensive care patients
Maja Karaman Ilić
; Zagreb University Hospital Center
Goran Madžarac
Irena Babić
Boris Milavić
Sažetak
The aim of this study was to assess the eff ect of fi beroptic aspiration and diluted surfactant administration on aff ected lungs in
children with atelectasis. A convenience sample of 18 mechanically ventilated children were analyzed in this single center prospective
study. The children had fi rst been treated unsuccessfully by respiratory physical therapy, after which they underwent fi beroptic
aspiration. After aspiration, nine children were randomly selected to receive therapeutic lavage with diluted porcine surfactant; the
remaining nine received the same quantity of saline solution. Several parameters of lung function, including positive end-expiratory
pressure (PEEP) and oxygenation index (OI), as well as lung x-ray images were determined before aspiration and lavage, then at 6
and 12 h after lavage. In both groups, most of the measured parameters showed improvement from baseline at 6 h after treatment.
Improvement was even more signifi cant 12 h after treatment. The surfactant group showed signifi cant improvement in comparison
to the saline group. The impact of surfactant administration was most visible on the following parameters 12 h after treatment
(p<0.001 in all cases): PEEP 5.22 (SD 0.44) in the saline group vs. 3.44 (SD 0.73) in the surfactant group; OI 3.84 (SD 1.13) vs. 2.1 (SD
0.38); and mean airway pressure (MAP) 8.56 (SD 0.88) vs. 6.33 (SD 0.5). In conclusion, fi beroptic aspiration is an effi cient treatment in
pediatric intensive care patients. The observed benefi cial eff ects of therapeutic lavage with diluted surfactant should be confi rmed
prospectively in a larger number of patients.
Ključne riječi
bronchoalveolar lavage; pulmonary surfactants; pulmonary atelectasis; intensive care units, pediatric
Hrčak ID:
142404
URI
Datum izdavanja:
26.3.2015.
Posjeta: 2.080 *