Acta clinica Croatica, Vol. 42 No. 1, 2003.
Recenzija, Prikaz slučaja
The Pathogenesis of Bronchial Hyperreactivity in Patients with Allergic Rhinitis
Ivan Grbac
Sonja Martinac
Marijka Šokčević
Sanja Rončević
Vlado Petric
Vladimir Stančić
Sažetak
Bronchial hyperreactivity denotes an enhanced bronchial response to usual physiological stimuli, and can manifest with cough or paroxysmal cough through tussive syncope and bronchospasm. Bronchial hyperreactivity can be transient or permanent. Transient bronchial hyperreactivity occurs in acute inflammation of the upper and lower airways, and manifests with dry irritation cough that may persist for up to two months. Permanent bronchial hyperreactivity is found in 10% - 50% of patients with allergic rhinitis, 50% of patients with chronic bronchitis, and 100% of patients with asthma. The pathophysiological mechanism of bronchial hyperreactivity in patients with allergic rhinitis has not yet been fully clarified, however, the following theories have been implicated: loss of nasal function, direct aspiration of inflammatory secretion and antigens, aerogenic transfer of antigens depending on particle size, gastroesophageal reflux, neurogenic mechanisms including the action of neuropeptides in the onset of neurogenic inflammation, and the concept of allergic reaction as a systemic response to local antigen presentation. It should be noted that bronchial hyperreactivity is not asthma; however, the clinical manifestation of asthma is just a matter of time. Therefore, allergic rhinitis should be considered a predisposing factor for the occurrence of asthma.
Ključne riječi
Rhinitis allergic, etiology, physiopathology; Bronchi, physiology; Asthma, physiopathology; Epithelial cells, physiology
Hrčak ID:
14587
URI
Datum izdavanja:
3.3.2003.
Posjeta: 4.042 *