Pregledni rad

An approach to the patient with positive history of penicillin allergy

Mirjana Stanić Benić orcid.org/0000-0002-4123-9937 ; Odjel za kliničku farmakologiju, KBC Rijeka, Rijeka
Vera Vlahović-Palčvevski ; Odjel za kliničku farmakologiju, KBC Rijeka, Rijeka

Sažetak

Although exact frequency of drug – induced allergic reactions is not known, they account for approximately 10 % of all adverse drug reactions. The frequency of some type of penicillin reactions in general population ranges between 0.7 % and 10 %. Actual incidence of penicillin allergy is even lower since in the past many non-allergic effects of antibiotic attributed to allergies. In suspected penicillin allergic patients, it is important to assess the allergological status. Inappropriate avoidance the use of penicillin, which is inexpensive and, in most cases, safe drug, increases the costs of hospitalization, morbidity and mortality of patients. In contrast, the use of penicillin in allergic patients can lead to serious adverse outcomes including death. The most efficient method of determining penicillin allergy is skin allergy test. Drug provocation testing is the most appropriate for a patient who is unlikely to be allergic to penicillin. This presupposition is based on the data of negative results of skin testing and not persuasive clinical history for penicillin allergy. Administration of an unrelated antibiotic or desensitization to penicillin are treatment options in patients prone to penicillin allergy. Desensitization is a procedure that encourages temporary tolerance to penicillin. It is treatment of choice in life – treating bacterial infection when there are no treatment alternatives and it need to be performed under close observation. Commercially available diagnostic tests are considered to be safe in detecting penicillin allergy in patients with suspected history for penicillin allergy.

Ključne riječi

allergy; anaphylactic reactions; drugs; penicillin; test

Hrčak ID:

152935

URI

https://hrcak.srce.hr/152935

Datum izdavanja:

1.3.2016.

Podaci na drugim jezicima: hrvatski

Posjeta: 12.071 *