Kratko priopćenje

SAFETY OF THE ELECTROCONVULSIVE THERAPY AND AMISULPRIDE COMBINATION

Rozália Takács ; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Zsolt Iványi ; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Gabor S. Ungvari ; University of Notre Dame, Australia, Marian Centre, Perth, Australia
Gábor Gazdag orcid.org/0000-0002-6914-8041 ; Consultation–Liaison Psychiatric Service, Szent István and Szent László Hospitals, Budapest, Hungary

Sažetak

Background: Electroconvulsive therapy is frequently considered when pharmacotherapy is ineffective. In such cases the
combination of the two treatment modalities are commonly used. Amisulpiride, a second generation antipsychotic drug is used in the
treatment of schizophrenia and psychotic depression. When amisulpiride is ineffective as a monotherapy, combination with ECT
could be an option to enhance its efficacy. To the best of our knowledge, to date there have been no data about the safety of this
combination.
Subjects and methods: Medical notes of all patients who were given ECT while on amisulpiride were selected from the archives
of the Department of Psychiatry, Semmelweis University Medical School, Budapest, covering a 10-year period. A randomly selected
matched control group was formed from patients who underwent ECT but were not taking amisulpiride. Patients in both groups also
received a variety of psychotropic drugs other than amisulpide. Side effects were compared between the two groups of patients.
Results: Twenty patients received amisulpride with ECT. The most common side effects were headache, hypertension,
tachycardia, nausea, dizziness, confusion, psychomotor agitation, sialorrhea, and prolonged seizure activity. All adverse effects
resolved within 24 hours. No side effects of any kind were observed in 7 and 8 cases in the study and control groups, respectively.
Conclusions: This was the first study that examined the safety of amisulpride-ECT combination in schizophrenia. Comparing the
side-effects between the study and control groups, no significant differences were detected in terms of their types or frequency. The
amisulpiride-ECT combination appears to be a safe treatment option.

Ključne riječi

electroconvulsive therapy – amisulpiride - side-effects - safety

Hrčak ID:

159850

URI

https://hrcak.srce.hr/159850

Datum izdavanja:

4.3.2013.

Posjeta: 1.035 *