Original scientific paper

GHRELIN AND LIPID LEVELS IN PANIC DISORDER BEFORE AND AFTER TREATMENT AND THEIR RELATIONSHIP WITH AGORAPHOBIA

Isil Gogcegoz Gul ; Department of Psychiatry, NP Istanbul Hospital, Uskudar University, Istanbul, Turkey
Birgul Elbozan Cumurcu ; Department of Psychiatry, Inonu University Faculty of Medicine, Malatya, Turkey
Rifat Karlidag ; Department of Psychiatry, Inonu University Faculty of Medicine, Malatya, Turkey
Yusuf Turkoz ; Department of Biochemistry, Inonu University Faculty of Medicine, Malatya, Turkey

Abstract

Background: We aimed to evaluate serum ghrelin (GHR) levels and lipid profile in panic disorder (PD), with and without
agoraphobia, and to compare these parameters before and after treatment.
Subjects and methods: The GHR and lipid profiles were measured in blood samples taken from 31 PD patients with
agoraphobia, 22 PD patients without agoraphobia, and 53 control group subjects. 23 of the 53 patients who were prescribed 20 to
40 mg/day paroxetine had continued treatment. The 23 patients who had continued treatment were measured again at the end of
twelve weeks.
Results: The GHR and triglyceride (TRG), total cholesterol (Total-C), low-density lipoproteins (LDL-C), and very low-density
lipoproteins (VLDL-C) levels were higher in the PD with agoraphobia group than the PD without agoraphobia and control groups.
The 23 patients that had continued their treatment were re-evaluated, and the serum GHR, Total-C levels, and BMI after treatment
were significantly decreased, compared to the values before treatment.
Conclusions: There may be a pathophysiological relationship between the GHR and lipid profiles that interact with each other
in PD. In fact, this relationship was more marked in PD with agoraphobia than in PD without agoraphobia.

Keywords

panic disorder – agoraphobia – ghrelin – lipid - cholesterol

Hrčak ID:

162464

URI

https://hrcak.srce.hr/162464

Publication date:

23.9.2015.

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