Izvorni znanstveni članak
Plasma Content of Glucose, C-reactive Protein, Uric Acid and Cholesterol in Male, Female and Ovariectomized Rats upon Acute and Chronic Stress – a Path for Development of Cardiovascular Diseases
Marta Balog
orcid.org/0000-0002-7842-4781
; Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Dražen Mlinarević
; Department of Emergency Medicine Osijek, Osijek, Croatia
Vatroslav Šerić
; Department for Biochemical Diagnostic, University Hospital Centre Osijek, Croatia
Milan Miljanović
; Department of Medical Biology and Genetics, Faculty of Medicine, J.J.Strossmayer University of Osijek, Osijek, Croatia
Robert Blažeković
; Department of Cardiac and Transplantation Surgery, University Hospital Dubrava, Zagreb, Croatia
Ivan Večeslav Degmečić
; Department of Medical Biology and Genetics, Faculty of Medicine, J.J.Strossmayer University of Osijek, Osijek, Croatia
Senka Blažetić
; Department of Biology, J.J.Strossmayer University of Osijek, Osijek, Croatia
Ivana Oršolić
; Department of Biology, J.J.Strossmayer University of Osijek, Osijek, Croatia
Sandor G. Vari
; International Research and Innovation Management Program, Cedars - Sinai Medical Center, Los Angeles, CA, USA
Marija Heffer
; Department of Medical Biology and Genetics, Faculty of Medicine, J.J.Strossmayer University of Osijek, Osijek, Croatia
Sažetak
To explore sex differences in cardiovascular function under stress, we analyzed plasma levels of glucose, C-reactive protein (CRP), uric acid and cholesterol in male, female and ovariectomized rats under acute and chronic stress. Glucose tolerance test (GTT) was performed in all rats before any stress was performed, as well as later in the chronic stress experiment. GTT in control animals showed the same trend as in chronically stressed. Male rats showed the highest plasma level of glucose and uric acid upon acute stress in comparison between the other two groups. Ovariectomized rats reached the highest concentration of plasma cholesterol during acute and chronic stress, respectively and also the highest plasma concentration of CRP during acute stress. Stress, as a risk factor of metabolic syndrome, affected biochemical parameters in males upon acute more than upon chronic stress, but the opposite was observed in female rats. Gender differences supported by ovariectomy show that stress managing could be affected by sexual hormones.
Ključne riječi
cardiovascular diseases; chronic stress; acute stress; cholesterol; glucose; uric acid; C-reactive protein; ovariectomy; estrogens; plasma
Hrčak ID:
166077
URI
Datum izdavanja:
16.9.2015.
Posjeta: 687 *