Professional paper

Carbamazepine overdose presenting as a diabetes insipidus – like condition in a child

Madhuradhar Chegondi ; Division of Critical Care Medicine Nemours Children’s Hospital 13535 Nemours Parkway, Orlando, FL 32827

Abstract

Carbamazepine is a commonly used antiepileptic medication. In overdoses it can produce various side effects involving neurological, cardiac, hematological and endocrinal systems. Inappropriate secretion of Anti Diuretic Hormone (ADH) is a well-known complication of carbamazepine toxicity. We are reporting an unusual complication in an adolescent girl with intentional carbamazepine overdose. A sixteen year old female with carbamazepine ingestion presented to our hospital with altered sensorium. On admission she was found to have a very high serum carbamazepine level and metabolic acidosis. In contrast to the possible inappropriate secretion of ADH, as an adverse effect of carbamazepine, her hospital course was complicated with a diabetes insipidus – like condition following treatment with multiple doses of activated charcoal and sodium bicarbonate therapy.

Keywords

Carbamazepine; Diabetes Insipidus; activated charcoal; child

Hrčak ID:

170143

URI

https://hrcak.srce.hr/170143

Publication date:

1.12.2015.

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