Pregledni rad

https://doi.org/10.21860/medflum2017_173375

Wound healing process and dipeptidyl peptidase IV

Lara Batičić Pučar orcid.org/0000-0002-2837-4157 ; Zavod za kemiju i biokemiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Antonijo Grčić ; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Ester Pernjak Pugel ; Zavod za histologiju i embriologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Dijana Detel orcid.org/0000-0001-8986-0880 ; Zavod za kemiju i biokemiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Jadranka Varljen ; Zavod za kemiju i biokemiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka

Sažetak

Wound healing is a dynamic process occurring in multiple interdependent stages that include a regulated interaction between different cell types, extracellular matrix, proteases and their substrates. Increasing scientific evidence emphasizes the importance of proteases playing crucial roles in the regulation of processes of wound healing. Dipeptidyl peptidase IV (DPP IV/CD26, EC 3.4.14.5), the main member of the DPP IV family of proteins, is a ubiquitous multifunctional transmembrane as well as soluble glycoprotein, acting as a proteolytic and costimulation molecule, and binding protein. It is expressed on the surface different cell types, including epithelial, endothelial cells and lymphocytes. It has been shown to play a significant role in different physiological as well as pathological processes. DPP IV/ CD26 was largely investigated given its ability to maintain glucose homeostasis. Moreover, since positive effects of DPP IV/CD26 inhibition in healing of chronic diabetic foot ulcers as well as other pathologies have been shown, growing efforts are made in order to elucidate its mechanisms of action. It is known that DPP IV/CD26 is involved in the regulation of cell adhesion, migration, apoptosis, angiogenesis and extracellular matrix degradation, which are all key processes in wound healing. Previous studies indicated that DPP IV/CD26 plays a particularly relevant role in skin regeneration where it was found to mediate inflammatory processes and influence epithelialization of wounds. Therefore, the aim of this review was to summarize crucial findings regarding wound healing as well as new insights about the involvement of DPP IV/CD26 in tissue regeneration.

Ključne riječi

angiogenesis; CD26; dipeptidyl peptidase IV; wound healing

Hrčak ID:

173375

URI

https://hrcak.srce.hr/173375

Datum izdavanja:

1.3.2017.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.550 *