Medicina, Vol. 53 No. 1, 2017.
Izvorni znanstveni članak
https://doi.org/10.21860/medflum2017_173376
Review of gastrointestinal stromal tumors and contribution of dog1 immunohistochemical marker in diagnostics: A single tertiary centerb experience
Andrej Belančić
orcid.org/0000-0001-7848-6600
; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Luka Vranić
; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Ivan Vuksan
; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Dora Fučkar Čupić
; Zavod za patologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Dražen Kovač
; Zavod za patologiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Sažetak
Aim: To present the experience of Clinical Hospital Center (CHC) Rijeka, Department of Pathology in diagnosing gastrointestinal stromal tumors (GIST) in a 10-year period and to demonstrate consequential characteristics of this mesenchymal tumor. Also the aim was to present the sensitivity of DOG1 (Discovered on GIST) immunohistochemical marker, and to compare it with CD117 and vimentin results. Materials and methods: Searching the Pathology Department database, 89 GISTs were found in the period from 2005 to 2015. Epidemiologic and clinicopathological data: age, gender, dimension, localization, immunohistochemical charachteristics, also mitotic rate and malignant potential as two most important parameters for prognostic group estimation, were statistically analyzed. Results: Median age was 64, range from 17 to 93. 48.3 % of patients were male and 51.7 % were female. Most GISTs (48.3 %) were localized in stomach. Spindle cell morphology was present in 84.3 % GISTs, epitheloid in 3.4 % and mixed in 12.3 % tumors. According to the prognostic groups, malignant potential was assigned. The biggest portion, 65.2 % of tumors, were benign. Malignant potential was present in 33.7 % of cases, while 1.1 % had insecure malignant potential. 25 GISTs were stained with DOG1 and this marker has shown 100 % sensitivity, while CD117 (88 %) and vimentin (60 %) have given inferior results. Conclusions: DOG1 is the most sensitive marker in immunohistochemical staining of GISTs. Hence, it’s usage has provided a step forward in differentiation of GISTs from other mesenchymal tumors. This review, based on a 10-year experience of CHC Rijeka, may make an important progress in pathohistological diagnostics of GISTs in Croatia.
Ključne riječi
CD117 antigen; gastrointestinal stromal tumors; human DOG1 protein; immunohistochemistry
Hrčak ID:
175252
URI
Datum izdavanja:
1.3.2017.
Posjeta: 3.049 *