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INFLAMMATORY BOWEL DISEASE AND KIDNEY– IS THERE A CONNECTION?

IVANA MIKOLAŠEVIĆ ; Klinički bolnički centar Rijeka, Klinika za nefrologiju, dijalizu i transplantaciju bubrega i Klinika za gastroenterologiju, Rijeka, Hrvatska
SANDRA MILIĆ ; Klinički bolnički centar Rijeka, Klinika za gastroenterologiju, Rijeka, Hrvatska
BRANKICA MIJANDRUŠIĆ-SINČIĆ ; Klinički bolnički centar Rijeka, Klinika za gastroenterologiju, Rijeka, Hrvatska
VESNA LUKENDA ŽANKO ; Opća bolnica “Dr. Josip Benčević”, Odjel za internu medicinu, Slavonski Brod, Hrvatska
ITA JELIĆ PRANJIĆ ; Klinički bolnički centar Rijeka, Klinika za nefrologiju, dijalizu i transplantaciju bubrega,Rijeka, Hrvatska
VOJKO MAVRINAC ; Klinički bolnički centar Rijeka, Klinika za gastroenterologiju, Rijeka, Hrvatska
IRENA KRZNARIĆ-ZRNIĆ ; Klinički bolnički centar Rijeka, Klinika za gastroenterologiju, Rijeka, Hrvatska
SANJIN RAČKI ; Klinički bolnički centar Rijeka, Klinika za nefrologiju, dijalizu i transplantaciju bubrega,Rijeka, Hrvatska
DAVOR ŠTIMAC ; Klinički bolnički centar Rijeka, Klinika za gastroenterologiju, Rijeka, Hrvatska
LIDIJA ORLIĆ ; Klinički bolnički centar Rijeka, Klinika za nefrologiju, dijalizu i transplantaciju bubrega,Rijeka, Hrvatska

Sažetak

The aim of the present study was to investigate whether patients with inflammatory bowel disease (IBD) have some degree of renal involvement. Furthermore, we investigated whether this connection is related to active bowel disease. In this cross-sectional study, 50 patients diagnosed with IBD, mean age 47.1±16.5 years, were recruited from September 2012 to September 2013. The diagnosis of IBD was based on clinical history, endoscopic, histological and radiological findings. Disease activity was assessed using the UC activity indeks (UCAI) for ulcerative colitis (UC) and Crohn’s disease activity index (CDAI) for Crohn’s disease (CD). There were 38% of UC patients and 62% of CD patients. The prevalence of abnormal albuminuria in UC and CD patients was 21.1% and 29%, respectively. There was a high negative correlation between duration of bowel disease and 24-h albuminuria in UC patients, as well as a high correlation between albumin-creatinine ratio (ACR) and UCAI score in UC patients, but these correlations were not statistically significant, probably due to the small number of UC patients. On the other hand, estimated glomerular filtration rate (eGFR) showed negative correlation with disease activity in CD patients (r=-0.569; p=0.05), while there was no statistically significant correlation between active UC and eGFR (r=0.343; p=NS). In conclusion, abnormal albuminuria is quite frequent in patients with IBD. It seems that patients with IBD have some degree of glomerular damage, mainly those with CD. Collaborative, prospective studies conducted by gastroenterologists and nephrologists are needed to investigate this association.

Ključne riječi

inflammatory bowel disease; extraintestinal manifestation; kidney

Hrčak ID:

180118

URI

https://hrcak.srce.hr/180118

Datum izdavanja:

6.4.2017.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.291 *