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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 71 No. 1, 2017.

Original scientific paper

ASSESSMENT OF MULTIPLE AREAS ON MAGNETIC RESONANCE MIDSAGITTAL BRAIN IMAGES IN MULTIPLE SCLEROSIS PATIENTS

RENGIN KOSIF orcid id orcid.org/0000-0002-0334-1658 ; Abant Izzet Baysal University Medical Faculty, Department of Anatomy, Bolu, Turkey
SULE AYDIN TURKOGLU ; Department of Neurology, Bolu, Turkey
ELIF SULTAN BOLAC ; Department of Neurology, Bolu, Turkey
EMINE DAGISTAN ; Department of Radiology, Bolu, Turkey

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Abstract

The aim of the study was to compare the first and last magnetic resonance images (MRIs) in patients diagnosed with multiple sclerosis (MS) with MRIs of normal subjects. We wanted to investigate the region initially involved in MS patients. In this retrospective study, midsagittal plane was explored on brain MRIs taken at the time when MS diagnosis was established and the last MRI was obtained following treatment for MS. Comparison was done between healthy subjects and patients diagnosed with MS. The measures included the area of corpus callosum, cerebrum, cerebellum, pons, bulbus, fourth ventricle and pituitary gland. As a result, while there was growth in the fourth ventricle area, there was shrinkage in the other areas in MS patients. In women, the tissues involved at the beginning of the disease were pituitary gland, cerebrum and bulbus, and in men corpus callosum and cerebrum. Atrophy was not time-dependent. Assessment of the correlation between the Expanded Disability Status Scale (EDDS) and atrophy revealed an increase in EDDS (disease progression) to be associated with a decrease in the area of cerebrum and corpus callosum in men, and an increase in the fourth ventricular area in women. In conclusion, we demonstrated that pituitary gland atrophy develops in the early stage of MS, especially in women. Additional studies are needed to investigate the phenomenon of early pituitary and bulbus atrophy in women versus late atrophy of these tissues in men.

Keywords

multiple sclerosis; brain; midsagittal areas; assessment

Hrčak ID:

184901

URI

https://hrcak.srce.hr/184901

Publication date:

19.7.2017.

Article data in other languages: croatian

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