Ostalo
Mast cell disorders, melanoma and pancreatic carcinoma: from a clinical observation to a brief review of the literature.
Giovanni Paolino
Maria Belmonte
Stefania Trasarti
Michelina Santopietro
Luisa Bizzoni
Mara Riminucci
Luisa Cardarelli
Emilia Iannella
Marcello Albanesi
Elisa Moliterni
Dario Didona
Stefano Calvieri
Robin Foà
Fiorina Giona
Sažetak
Mastocytosis can be associated with other clonal or non-clonal hematologic diseases as well as a variety of non-hematologic malignancies. A 75-year-old Caucasian male patient was referred to us with a 5-month history of neutrophilic leukocytosis and mild splenomegaly. He had developed a cutaneous melanoma sixteen years ago. According to the clinical and pathological features, a final diagnosis of systemic mastocytosis was established. The patient started treatment with interferon-α at a dose of 3 MIU/day, combined with low doses of prednisone. We observed a rapid disappearance of symptoms. Unfortunately, after 3 months a diagnosis of pancreatic adenocarcinoma was established. A review of the literature suggests that mastocytes could have a pivotal role in several malignancies. Different chemokines, mitogenic factors, chemical mediators of inflammation, and specific gene mutations could explain the association between mastocytosis and other hematologic and non-hematologic disorders.
Ključne riječi
Mastocytosis; Melanoma; Pancreatic Neoplasms; Tryptases
Hrčak ID:
185017
URI
Datum izdavanja:
20.7.2017.
Posjeta: 1.285 *