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Early onset of vulvar cancer and multiple sclerosis therapy: case report

Ilija Alvir ; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mario Puljiz ; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Lucija Kostić ; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Damir Danolić ; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ivica Mamić ; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Darko Tomica ; Department of Gynecology and Obstetrics, General Hospital Scheibbs, Scheibbs, Austria

Abstract

Vulvar cancer is a rare disease among young women. Risk factors for vulvar cancer are smoking, chronic dermatitis and human papilloma virus infection. However, no correlation between multiple sclerosis and increased risk of cancer has been established. We present a case of vulvar cancer in 35 year old women with multiple sclerosis. Radical vulvectomy with right-sided inguinofemoral lymphadenectomy was performed. Pathohistological analysis confi rmed the diagnosis of a squamous cell carcinoma, grade II, International Federation of Gynecology and Obstetrics (FIGO) IB. Adjuvant radiotherapy was not indicated. After two years of follow up, there was no evidence of the recurrence. The occurrence of vulvar cancer in multiple sclerosis patients may be coincidental. Nevertheless, the long term use of
immunomodulatory drugs in multiple sclerosis and incidence of cancer may be associated.

Keywords

vulvar cancer; multiple sclerosis; risk factors; case report

Hrčak ID:

190247

URI

https://hrcak.srce.hr/190247

Publication date:

10.12.2015.

Article data in other languages: croatian

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