Original scientific paper
https://doi.org/10.22514/SV132.112017.13
Inhaled dry salt micro particles in the treatment of bronchopulmonary dysplasia: a five case series report
CATALIN G CIRSTOVEANU
orcid.org/0000-0002-7778-0477
; “Carol Davila” University of Medicine and Pharmacy, No. 20 Constantin Brancoveanu Boulevard, 4th District
NINE LUMINITA
ALEXANDRA I. ISTRATE –BARZAN
BARASCU ILEANA
STEFAN MANOLACHE
MIHAELA BIZUBAC
ALINA GAIDUCHEVICI
Abstract
Background. Despite current medical advances,
to this day there is no single medical
intervention to effectively prevent or
treat bronchopulmonary dysplasia (BPD)
in both preterm and term infants. Along
with protective ventilation strategies, various
drugs are being used or are being researched
at this very moment, with the sole
purpose of improving the general outcome
for these patients. Inhaled dry salt micro
particles therapy is now one of them.
Materials and methods. This report presents
five patients, diagnosed with severe
BPD. All of them received, complementary
to classical BPD management and
respiratory support, continuous inhaled
dry salt micro particles, via SaltMed cartridges,
for a period of 12 to 30 days. After
only 24 hours of administration, we were
able to observe a significant improvement
in respiratory function and dynamics. It
was possible to use a lower fraction of inspired
oxygen (FiO2), mean airway pressure
(MAP) and peak inspiratory pressure
(PIP) in all mechanically ventilated patients.
Higher tidal volumes were recorded
and we observed improvement in oxygenation
indexes.
Conclusion. Continuously inhaled dry salt
micro particles, administered complementary
to classic BPD management, could
improve respiratory and overall morbidity
and mortality in infants with any form
of BPD. Further study of these possible
effects is needed, as there is no data published
on this matter so far.
Keywords
bronchopulmonary dysplasia (BPD); inhaled dry salt micro particles; oxygenation index (OI); fraction of inspired oxygen (FiO2); mean airway pressure (MAP)
Hrčak ID:
190621
URI
Publication date:
12.12.2017.
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