Review article

https://doi.org/10.20471/acc.2017.56.03.19

Hepatic Osteodystrophy: A Global (Re)View of the Problem

Ecaterina-Constanța Barbu ; Carol Davila University of Medicine and Pharmacy, Matei Balş National Institute for Infectious Diseases, I. Cantacuzino Clinical Hospital, Bucharest, Romania
Cristina-Emilia Chițu-Tișu ; Carol Davila University of Medicine and Pharmacy, Matei Balş National Institute for Infectious Diseases, I. Cantacuzino Clinical Hospital, Bucharest, Romania
Mihai Lazăr ; Carol Davila University of Medicine and Pharmacy, Matei Balş National Institute for Infectious Diseases
Cristina Olariu ; Carol Davila University of Medicine and Pharmacy, Matei Balş National Institute for Infectious Diseases
Mihai Bojincă ; Carol Davila University of Medicine and Pharmacy, I. Cantacuzino Clinical Hospital, Colentina Clinical Hospital, Bucharest, Romania
Răzvan Adrian Ionescu ; Carol Davila University of Medicine and Pharmacy, Colentina Clinical Hospital, Bucharest, Romania
Daniela Adriana Ion ; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Ioana Anca Bădărău ; Carol Davila University of Medicine and Pharmacy, Bucharest, Romani

Abstract

Hepatic osteodystrophy is a common and frequently untreated complication, manifested as osteoporosis or osteopenia, encountered in the evolution of chronic liver diseases. Th is article provides a narrative review of hepatic osteodystrophy. Th e aim is to revise the prevalence, pathophysiology, diagnosis and management of hepatic osteodystrophy. We searched medical literature via PubMed, Google Scholar, Wiley, Science Direct, and Springer Link using respective keywords to obtain data on low bone mineral density connected to chronic liver diseases. Many studies have reported an increased prevalence of osteoporosis/osteopenia in patients with chronic liver diseases. Th e pathogenesis is multifactorial, involving genetic factors, vitamin defi ciencies, proinfl ammatory cytokines, hypogonadism, hyperbilirubinemia, antiviral therapy, corticosteroid drugs, and lifestyle factors. Th e management of patients should include individualized assessment for fracture risk factors and bone mineral density. Vitamin D and calcium supplementation should be recommended in all patients with chronic liver diseases and osteoporosis. Bisphosphonates are the most effi cient drugs used in the treatment of hepatic osteodystrophy. In the future, it is necessary to defi ne better the management and specifi c treatment of hepatic osteodystrophy for prevention of fragility fractures and to improve the patient quality of life.

Keywords

Bone diseases, metabolic – diagnosis; Bone diseases, metabolic – physiopathology; Osteoporosis; Fractures, bone; Bisphosphonates

Hrčak ID:

191667

URI

https://hrcak.srce.hr/191667

Publication date:

1.9.2017.

Article data in other languages: croatian

Visits: 3.128 *