Medicinski vjesnik, Vol. 30 No. (1-2), 1998.
Professional paper
Left ventricular volume determination using a count- based method requiring blood sampling and rest-stress radionuclide ventriculography with Tc-99m labelled red blood cells
Nedeljko Topuzović
Ivanka Žuro-Tijardović
Aleksandar Rusić
Branislav Krstonošić
Jasna Gardašanić
Juraj Smoje
Ivan Karner
Abstract
Aim: The purpose of this study was to investigate the changes in blood activity during rest, exercise and recovery, and to assess its influence on left ventricular (LV) volume determination using the count-based method requiring blood sampling and Tc-99m labelled red blood cells.
Methods: 31 patients underwent rest-stress radionuclide ventriculography: in 17 patients red blood cells were labelled using Tc-99m (Group I) in vivo, and in 14 patients (Group II) by the modified in vivo/in vitro method. LV volumes were determined by a count-based method using corrected count rate in blood samples obtained during rest, peak exercise and after recovery.
Results: In Group I at stress, the blood activity increased by 25.1 ± 6.4%, p<0.001, as compared to the rest level, and in Group II by 12.8 ± 4.5%, p<0.05. This had profound effects on LV volume determinations if only one rest blood aliquot was used: during exercise, the LV volumes were significantly overestimated by 32.1 ± 10.3%, p<0.001 in Group I, and by 10.7 ± 6.4%, p<0.05 in Group II. The changes in blood activity between stress and recovery were not significantly different between the groups.
Conclusion: The use of solely a single blood sample as volume aliquot in rest-stress studies, when red blood cells were labelled using Tc-99m, leads to erroneous overestimation of cardiac volumes, due to significant changes in blood radioactivity during exercise and recovery.
Keywords
radionuclide ventriculography; left ventricular volume; Tc-99m labelled red blood cells
Hrčak ID:
192083
URI
Publication date:
1.12.1998.
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