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https://doi.org/10.20471/acc.2017.56.04.34

Myasthenia Gravis Associated with Thymoma and Aplastic Anemia: Case Report

Lidija Dežmalj Grbelja orcid.org/0000-0001-9535-9785 ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Radovan Vrhovac ; University Department of Hematology, Zagreb University Hospital Center, Zagreb, Croatia
Monika Ulamec ; University Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia

Abstract

Myasthenia gravis is associated in 10 to 15 percent of patients with thymic tumors, rarely with aplastic anemia. We report a 45-year-old male diagnosed with myasthenia gravis ­associated with thymoma. We started treatment with pyridostigmine. After thymectomy, the patient ­received 30 irradiation sessions. In the postoperative course, he had mild worsening of myasthenia gravis, which improved with prednisone. Five months later, he developed severe aplastic anemia. He was dependent on blood supplement. After allogeneic transplantation of bone marrow, he improved but later he ­developed graft versus host disease. Myasthenia gravis was under good control with 480 mg of ­pyridostigmine per day.

Keywords

Myasthenia gravis; Anemia, aplastic; Thymoma; Pyridostigmine bromide; Thymectomy; Graft vs host disease

Hrčak ID:

195544

URI

https://hrcak.srce.hr/195544

Publication date:

15.12.2017.

Article data in other languages: croatian

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