Medicinski vjesnik, Vol. 23 No. (1-2), 1991.
Izvorni znanstveni članak
Comparison between famotidine (20 mg at bed time) and ranitidine (150 mg at bed time) in the prevention of duodenal ulcer relapse
Aleksandar Včev
Ivan Čandrlić
Dubravko Božić
Miroslav Volarić
Dubravko Paulini
Nikola Mićunović
Branimir Zelenka
Darko Horvat
Dubravka Tarle
Ivica Čandrlić, ml.
Boris Pospihalj
Andrijana Vegar
Sažetak
Famotidine given in a 20-mg dose at bed-time was compared to ranitidine administered in a dose of 150 mg at bed-time in the prevention of duodenal ulcer relapse during a six-month period. Seventy-one patients were included in the study. Patients were divided into two groups. Group 1 consisting 40 patients, after curing of acute illness, were treated with ranitidine, 150 mg at bed time, whereas group 2 consisting of 31 patients were treated with famotidine 20 mg at bed-time. Patients from both groups were additionally treated with antacide. After 3 months, one and no cases of relapse were recorded in groups 1 and 2, respectively. After 6 months, three cases of duodenal ulcer relapse were recorded in group 1 and two cases in group 2. Two out of three patients in group 1 and both patients in group 2 with duodenal ulcer relapse were smokers. There were no statistically significant differences between the two groups of patients in RBC, urea concentrations, creatinine and transaminases in blood after 3 and 6 months. No adverse side-effects were observed during the administration of either drug studied.
Ključne riječi
duodenal ulcer; famotidine; ranitidine
Hrčak ID:
195571
URI
Datum izdavanja:
1.12.1991.
Posjeta: 2.486 *