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Reactions with 1-Benzotriazolecarboxylic Acid Chloride. I. Synthesis of the 2,6-Bis(hydroxymethyl)pyridinedicarbamates

I. Butula ; Faculty of Pharmacy and Biochemistry, University of Zagreb
M. V. Proštenik ; »PLIVA« Pharmaceutical and Chemic,al Works, 41000 Zagreb, Croatia, Yugoslavia
V. Vela ; »PLIVA« Pharmaceutical and Chemic,al Works, 41000 Zagreb, Croatia, Yugoslavia

Sažetak

Some 2,6-bis(hydroxymethyl)pyridinedicarbamates VII were
synthesized by reaction of pyridinedimethanole (I) with carbamoylazoles
II-VI (azole=imidazole, benzimidazole, pyrazole, 1,2,4-triazole,
benzotriazole). It is confirmed that this reaction proceed via an
intermolecular elimination-addition acyl transfer mechanism including
in the first step the formation of an isocyanate. Carbamoylbenzotriazoles
Vla-i were prepared by aminolysis of 1-benzot,riazole-'
carboxylic acid chloride (VIII) obtained from benzotriazole and
phosgene.

Ključne riječi

Hrčak ID:

196158

URI

https://hrcak.srce.hr/196158

Datum izdavanja:

26.4.1978.

Posjeta: 813 *