Izvorni znanstveni članak
https://doi.org/10.22514/SV141.042018.9
Do we need an individual approach to atrial fIbrillation and adrenergic overload in the critically ill?
MATEJ PODBREGAR
; Cardiovascular Intensive Care Unite Clinical Department for Anaesthesiology and Surgical Intensive Care University Medical Centre Ljubljana
JURIJ MATIJA KALIŠNIK
Sažetak
Despite catecholamines being lifesaving
drugs, they can also be harmful. Adrenergic
overload is one of the major promoters of
supra- and ventricular arrhythmias, which
induce hemodynamic instability in the critically
ill. In this paper we will focus on the
pathophysiology of atrial fbrillation (AF),
the importance of adrenergic overload for
triggering AF, the importance of the autonomic
nervous system and fnally, we will
challenge the importance of decreasing
adrenergic load with selective and nonselective
β-blockers, which have diferent
efects on the metabolism in the severely
ill. We will also emphasize the importance
of an individual approach due to pharmacogenetic
diferences in β-adrenergic signalling.
Ključne riječi
catecholamine; atrial fibrillation; beta-blocker; metabolism; resting energy expenditure
Hrčak ID:
200437
URI
Datum izdavanja:
1.6.2018.
Posjeta: 1.150 *