Pregledni rad

Oncological counseling of patients and families with hereditary colorectal cancer

Tamara Žigman-Žarković ; Department of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Iva Kirac ; Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Tajana Silovski ; Department of Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Danko Velimir Vrdoljak ; Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia

Sažetak

Colorectal cancer (CRC) is the third most common malignancy in the world. Thirty percent of all CRC cases are hereditary or familial forms of the disease. Approximately 5% of them represent well defined hereditary syndromes. Colon cancer syndromes are inherited autosomal dominant diseases, with exception of MUTYH associated polyposis, which is inherited in autosomal recessive manner. Most of CRC syndromes also carry significant risk of developing cancers of extra
colonic localization.The clinician who deals with hereditary CRC patients should have a wide knowledge ofpresentation, genetics and cancer risks in hereditary CRC syndromes.In Croatia we donot have the center that systematically deals with CRC genetics, pharmacogenetics and hereditary CRC syndromes. Therefore, with this article, we systematically review the characteristics CRC syndromes.

Ključne riječi

hereditary colorectal cancer; familial adenomatous polyposis; Lynch syndrome

Hrčak ID:

200647

URI

https://hrcak.srce.hr/200647

Datum izdavanja:

27.12.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.301 *