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Archives of Industrial Hygiene and Toxicology, Vol. 69 No. 3, 2018.

Original scientific paper

https://doi.org/10.2478/aiht-2018-69-3137

Occupational exposure to cytotoxic drugs: the importance of surface cleaning to prevent or minimise exposure

Susana Viegas orcid id orcid.org/0000-0003-1015-8760 ; H&TRC- Health & Technology Research Center, ESTeSL - Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa1, Centro de Investigação em Saúde Pública, Escola Nacional de Saúde Pública, Universidade NOVA de Lisboa2, Lisbon, Portugal
Ana Cebola de Oliveira ; NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal
Elisabete Carolino ; H&TRC- Health & Technology Research Center, ESTeSL - Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal
Mário Pádua ; H&TRC- Health & Technology Research Center, ESTeSL - Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal

Full text: english pdf 461 Kb

page 238-249

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Abstract

Healthcare workers who prepare or administer cytotoxic agents run the risk of exposure, and the risks for health are real even at doses lower than those applied in cancer patients, because, in theory, no dose is safe. The most common and problematic route of exposure is through the skin, especially as work surfaces can remain contaminated even after cleaning. This pilot study aimed to demonstrate the importance of having an effective surface decontamination protocol by determining surface contamination with cyclophosphamide, 5-fluorouracil, and paclitaxel as the most common cytotoxic drugs in an oncology day service. Samples were collected before and after drug handling and analysed with high performance liquid chromatography with diode array detection (HPLC-DAD). Of the 29 samples collected before drug handling 23 were contaminated, five of which with more than one drug. Of the 30 samples collected after drug handling 25 were contaminated, eight of which with more than one drug. The two time points did not significantly differ, which evidences a widespread contamination and ineffective cleaning. This calls for revising the cleaning protocol and handling procedure to place contamination under control as much as possible.

Keywords

5-fluoroacil; contamination control; cyclophosphamide; HPLC-DAD; oncology day service; paclitaxel

Hrčak ID:

206038

URI

https://hrcak.srce.hr/206038

Publication date:

25.9.2018.

Article data in other languages: croatian

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