Medicina, Vol. 54 No. 4, 2018.
Izvorni znanstveni članak
https://doi.org/10.21860/medflum2018_207353
Mean platelet volume in laryngeal cancer – role in cancer staging
Damir Vučinić
orcid.org/0000-0002-5804-0799
; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Ivan Vuksan
; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Tamara Braut
; Klinika za otorinolaringologiju, kirurgiju glave i vrata, Klinički bolnički centar Rijeka, Rijeka
Blažen Marijić
; Klinika za otorinolaringologiju, kirurgiju glave i vrata, Klinički bolnički centar Rijeka, Rijeka
Gordana Žauhar
; Katedra za medicinsku fiziku i biofiziku, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Andrea Dekanić
; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Mira Krstulja
; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Gordana Zamolo
; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Sažetak
Aim: This study aimes to investigate alteration of MPV (mean platelet volume) in laryngeal cancer. The hypothesis is that different clinical stages of laryngeal cancer and histological characteristics may be the basis of the pathophysiological changes in size and number of platelets.
Materials and methods: Laboratory and clinical data were analysed retrospectively from 76 patients with laryngeal squamous cell carcinoma. Two main groups were formed upon TNM clasification: early stage and advanced stage laryngeal cancer. Furthermore, the patients were subdivided according to cancer degree of differentiation and presence of blood vessel invasion.
Results: Statisticly significant difference between early and advanced stage cancer in the demographic and smoking data was not found. The comparison of MPV values showed statistically significant difference (P=0,003) between early and advanced laryngeal cancer. Furthermore, platelet values were significantly higher in the advanced group (P <0,001). The patients with poor differentiated cancer had significantly lower MPV values (P=0,001) compared to the ones with well and moderate differentiated stage. The difference in platelet count in the same groups was not statistically significant (P=0,132). The MPV value was significantly lower (P <0,001) in the group with vascular invasion compared to the group without that cancer characteristic.
Conclusion: Our results suggest the possibility of using MPV values to help the clinician in prognosis of laryngeal cancer. Determining MPV values and platelet count is easily accessible and inexpensive method that provides useful information in everyday clinical practice.
Ključne riječi
laryngeal carcinoma; mean platelet volume; tumor staging
Hrčak ID:
207353
URI
Datum izdavanja:
1.12.2018.
Posjeta: 1.592 *