Sažetak sa skupa

SAPHO SYNDROME – CLINICAL SYMPTOMS, IMAGING AND TREATMENT – BASED ON A GROUP OF POLISH PATIENTS

Hanna Przepiera-Bedzak ; Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Poland
Marek Brzosko ; Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Poland

Sažetak

Background: Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a very rare disease presenting as a constellation of skin and osteoarticular symptoms.
Objectives: We studied clinical symptoms, imaging and treatment in 52 Polish SAPHO patients.
Methods: The following data were recorded: age, sex, disease duration, type of joint involvement, type of skin changes, bone scintigraphy results, HLA-B27, rheumatoid factor (RF), comorbidities and treatment. The patient’s pain due to the disease was assessed using a visual analogue scale (VAS). We also assessed the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI).
Results: SAPHO syndrome was more common in women with the mean age at diagnosis 50.0 years. All patients had a negative RF. 25% of 23 assessed patients had a positive HLA B-27 antigen. 88.5% of patients had palmoplantar pustulosis. Swelling and pain of sternoclavicular joints were the most common joint symptoms (present in 96.1 % of patients). Two patients (3.8%) had mandible involvement. Despite hypertension, the most prevalent comorbidities were hypothyroidism (9.8%), diabetes (9.8%) and depression (5.9%). DMARDs and antibiotics were useful in treatment.
Conclusions: Mandible involvement is a rare manifestation of SAPHO syndrome. Increased incidence of autoimmune diseases and depression was observed. DMARDs and antibiotics were useful in treatment.

Ključne riječi

Hrčak ID:

210770

URI

https://hrcak.srce.hr/210770

Datum izdavanja:

5.12.2018.

Posjeta: 414 *