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https://doi.org/10.15836/ccar2019.234

Estradiol impact on hypertension profile in obese patients

Juraj Jug orcid.org/0000-0002-3189-1518 ; University of Zagreb School of Medicine, Zagreb, Croatia
Rea Levicki ; Požega General County Hospital, Požega, Croatia
Ines Vinković ; University of Zagreb School of Medicine, Zagreb, Croatia
Filip Mustač ; University of Zagreb School of Medicine, Zagreb, Croatia
Martina Matovinović ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Lada Bradić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Martina Lovrić Benčić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia

Sažetak

Introduction: Obesity is a well-known risk factor for developing hypertension. Prehypertensive patients
(with an average 24h monitored blood pressure between 120/85 and 139/89mmHg) rarely get
physician’s attention despite their differences from non-hypertensive patients.1,2
Patients and Methods: We enrolled 42 obese female patients (age range from 26 to 69 years) from a
multidisciplinary weight management program (BMI range 30 to 49.9 kg/m2). Firstly, because of estradiol
levels, patients were divided into two groups, younger than 50 years (A) and older (B). Due to the
average values of patient’s ambulatory monitored blood pressure, patients were additionally put into
three groups (1 = below 120/85mmHg, 2 = between 120/85 to 139/89mmHg 3 = above 140/90mmHg). Systolic
dipping profile, estradiol levels, and average nocturnal heart rate were also checked.
Results: Prehypertensive obese patients older than 50 years (B)
had higher nocturnal heart rate (58.50 vs. 70.25/min; p<0.05).
Even though differences were found in younger patients, they
were not statistically significant. Systolic dipping profile was
different and age-dependent (Non-dippers A: 44.00%; B 82.35%;
p=0.02). The number of non-dippers in the younger group was
highest in group 2 (66% vs. 20% in group 1; p=0.03) while there
were no differences in the older group. The prehypertensive
group had very similar results to hypertensive patients. Estradiol
levels (Figure 1) were age independently lower in non-dippers (A:
185.5 vs. 201.07, NS; B: 71.9 vs. 87.0, NS) and also in hypertensive
patients (A: 111.0 vs 192.6 pmol/L, p=0.21; B: 59.0 vs. 98.0 pmol/L).
Conclusion: Our results showed that estradiol levels seem to be
protective in terms of blood pressure stability, systolic dipping
profile and nocturnal heart rate probably due to its impact on autonomic
nerve system functionality. Because of a small number
of patients further investigation is needed to prove the statistical
significance of this statement.

Ključne riječi

estradiol; prehypertension; obesity; hypertension.

Hrčak ID:

226703

URI

https://hrcak.srce.hr/226703

Datum izdavanja:

15.10.2019.

Posjeta: 1.114 *