Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2019.69

DOUBLE BLIND CONTROLLED STUDY OF ADDING FOLIC ACID TO FLUOXETINE IN THE TREATMENT OF OCD

Ümit Tural ; Department of Psychiatry, The Nathan S. Kline Psychiatric Research Institute, Orangeburg, New York, USA
Aytül Çorapçıoğlu ; Department of Psychiatry, Medical Faculty at the University of Kocaeli, Umuttepe Kocaeli, Turkey
Şükriye Boşgelmez ; Department of Psychiatry, Medical Faculty at the University of Kocaeli, Umuttepe Kocaeli, Turkey
Gültürk Köroğlu ; Department of Psychiatry, Medical Faculty at the University of Kocaeli, Umuttepe Kocaeli, Turkey
Hatice Ünver ; Department of Child and Adolescent Psychiatry, Medical Faculty at the University of Marmara, Istanbul, Turkey
Can Duman ; Department of Biochemistry, Medical Faculty at the University of Kocaeli, Umuttepe, Kocaeli, Turkey
Emin Önder ; Department of Psychiatry, Medical Faculty at the University of Kocaeli, Umuttepe Kocaeli, Turkey

Sažetak

Background: Folate is important for the synthesis of serotonin the neurotransmitter which plays a main role in OCD. We, therefore, explored the efficacy of folic acid as add on treatment to fluoxetine in a double blind study among patients with OCD.
Subjects and methods: A double blind, 12-week study comparing the efficacy of folic acid as add on treatment and placebo in patients with OCD was conducted on thirty six (36) patients. Patients were randomly assigned to folic acid (5 mg/day) or placebo group in addition to fluoxetine (40 mg/day). After the baseline assessment, on week 2, 4, 6, 8 and 12 assessments were performed by using YBOCS, HAM-D, HAM-A and CGI-S. Serum folate, erythrocyte folate, serum homocysteine and B12 levels were measured both baseline and the end of study.
Results: A mixed model repeated measures ANCOVA on Y-BOCS scores were used to determine the difference between folic acid and placebo groups. No significant differences were found in the ratios of gender or in the mean age, serum folic acid level, erythrocyte folate level, serum homocysteine level and serum B12 level between the treatment groups at the baseline. Consecutively scores collected over six measurements on YBOCS, HAM-D, HAM-A and CGI showed non-significant differences between folic acid and placebo groups.
Conclusion: None of the biological markers of one carbon metabolism were associated with the change in YBOCS scores. It may be assumed that there is no beneficial effect of folic acid addition to fluoxetine in the treatment of OCD.

Ključne riječi

OCD; fluoxetine; serum folate; red cell folate; serum homocysteine; vitamin B12

Hrčak ID:

235002

URI

https://hrcak.srce.hr/235002

Datum izdavanja:

4.4.2019.

Posjeta: 1.652 *