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https://doi.org/10.24869/psyd.2019.241

THE ASSOCIATION OF CATECHOL-O-METHYL-TRANSFERASE AND INTERLEUKIN 6 GENE POLYMORPHISMS WITH POSTTRAUMATIC STRESS DISORDER

Valdete Haxhibeqiri ; Department of Clinical Biochemistry, University Clinical Centre of Kosovo, Prishtina, Kosovo
Shpend Haxhibeqiri orcid.org/0000-0002-9984-1648 ; Institute of Kosovo Forensic Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Valdete Topciu-Shufta ; Department of Clinical Biochemistry, University Clinical Centre of Kosovo, Prishtina, Kosovo; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo
Ferid Agani ; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo
Aferdita Goci Uka ; Department of Psychiatry, University Clinical Centre of Kosovo, Prishtina, Kosovo
Blerina Hoxha ; Department of Psychiatry, University Clinical Centre of Kosovo, Prishtina, Kosovo
Alma Dzubur Kulenovic ; Department of Psychiatry, Clinical Centre University of Sarajevo, Bosnia and Herzegovina
Miro Jakovljević ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Esmina Avdibegović ; Department of Psychiatry University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina; School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
Nermina Kravić ; Department of Psychiatry University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina; School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
Mirnesa Muminović Umihanić ; Community Health Centre Živinice, Živinice, Bosnia and Herzegovina
Osman Sinanović ; School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
Emina Šabić Džananović ; Department of Psychiatry, Clinical Centre University of Sarajevo, Bosnia and Herzegovina
Abdulah Kučukalić ; Department of Psychiatry, Clinical Centre University of Sarajevo, Bosnia and Herzegovina
Sabina Kučukalić ; Department of Psychiatry, Clinical Centre University of Sarajevo, Bosnia and Herzegovina
Alma Bravo Mehmedbašić ; Department of Psychiatry, Clinical Centre University of Sarajevo, Bosnia and Herzegovina
Branka Aukst Margetić ; Department of Psychiatry, University Hospital Centre Sestre Milosrdnice, Zagreb, Croatia
Nenad Jakšić ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Ana Cima Franc ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Duško Rudan ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Marko Pavlović ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Romana Babić ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Elma Ferić Bojić ; Department of Genetics and Bioengeneering, International Burch University, Sarajevo, Bosnia and Herzegovina
Damir Marjanović ; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia
Nada Božina ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Christiane Ziegler ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Christiane Wolf ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Bodo Warrings ; Department of Psychiatry and Psychotherapy, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Katharina Domschke ; Department of Psychiatry and Psychotherapy, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Jürgen Deckert ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Dragan Babić ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina

Sažetak

Background: Posttraumatic stress disorder (PTSD) is a disorder that occurs in some people who have experienced a severe traumatic event. Several genetic studies suggest that gene encoding proteins of catechol O-methyl-transferase (COMT) may be relevant for the pathogenesis of PTSD. Some researchers suggested that the elevation of interleukin-6 (IL6) correlates with major depression and PTSD. The aim of this study was to investigate whether the single nucleotide polymorphisms COMT rs4680 (Val158Met) and IL6 rs1800795 are associated with PTSD and contribute to the severity of PTSD symptoms.
Subjects and methods: This study comprised 747 participants that experienced war between 1991 and 1999 in the South Eastern Europe conflicts. COMT rs4680 (Val158Met) and IL6 rs1800795 genotypes were determined in 719 participants (369 with and 350 without PTSD). The Mini International Neuropsychiatric Interview (M.I.N.I.), the Clinician Administrated PTSD Scale (CAPS) questionnaire and the Brief Symptom Inventory (BSI) were used for data collection.
Results: Regarding the COMT gene polymorphism, the results of the regression analyses for BSI total score were significant in the lifetime PTSD group in the dominant (P=0.031) and the additive allelic model (P=0.047). Regarding the IL6 gene, a significant difference was found for the recessive model predicting CAPS total score in the lifetime PTSD group (P=0.048), and indicated an association between the C allele and higher CAPS scores. n the allelic, genotypic and rezessive model, the results for BSI total score were significant in the lifetime PTSD group (P=0.033, P=0.028 and P=0.009), suggesting a correlation of the C allele with higher BSI scores
Conclusion: Although our nominally significant results did not withstand correction for multiple tests they may support a relevance of the COMT (Val158Met) and IL6 rs1800795 polymorphism for aspects of PTSD in war traumatized individuals.

Ključne riječi

war trauma; PTSD; COMT; IL6; gene polymorphism

Hrčak ID:

235154

URI

https://hrcak.srce.hr/235154

Datum izdavanja:

9.7.2019.

Posjeta: 732 *