Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2019.263

THE ROLE OF TAQI DRD2 (RS1800497) AND DRD4 VNTR POLYMORPHISMS IN POSTTRAUMATIC STRESS DISORDER (PTSD)

Blerina Hoxha ; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Afërdita Goçi Uka ; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Ferid Agani ; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo
Shpend Haxhibeqiri ; Institute of Kosovo Forensic Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Valdete Haxhibeqiri ; Department of Medical Biochemistry, University Clinical Center of Kosovo, Prishtina, Kosovo
Emina Sabic Dzananovic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Sabina Kucukalic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Alma Bravo Mehmedbasic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Abdulah Kucukalic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Alma Dzubur Kulenovic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Elma Feric Bojic ; Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina
Damir Marjanovic ; Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina; Institute for Anthropological Researches, Zagreb, Croatia
Nermina Kravic ; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina
Esmina Avdibegovic ; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina
Mirnesa Muminovic Umihanić ; Community Health Center Zivinice, Zivinice, Bosnia and Herzegovina
Nenad Jaksic ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Ana Cima Franc ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Dusko Rudan ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Miro Jakovljevic ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Romana Babic ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Marko Pavlovic ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Dragan Babic ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Branka Aukst Margetic ; Department of Psychiatry, University Hospital Sestre Milosrdnice, Zagreb, Croatia
Nada Bozina ; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia
Osman Sinanovic ; Department of Neurology, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina
Christiane Ziegler ; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
Bodo Warrings ; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany
Katharina Domschke ; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
Jürgen Deckert ; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany
Christiane Wolf ; Biomedical and Experimental Department, Faculty of Medicine, University of Medicine in Tirana, Albania
Gentian Vyshka ; Biomedical and Experimental Department, Faculty of Medicine, University of Medicine in Tirana, Albania

Sažetak

Background: Posttraumatic stress disorder (PTSD) is a complex stress related disorder, that follows a severe traumatic experience, characterized with an intense sense of terror, fear, and helplessness. The aim of this study is to identify associations of genetic variations within candidate genes DRD2 and DRD4 with various PTSD related phenotypes. PTSD lifetime and PTSD current subjects were analyzed separately, each of them were analyzed in a Case/Control design, as well as regarding BSI and CAPS within cases only.
Subjects and methods: 719 (487 male, 232 female) participants who had experienced war-related trauma between 1991 and 1999 in Bosnia and Hercegovina, Kosovo and Croatia were included in the study. Sociodemographic questionnaire, Clinician Administered PTSD Scale (CAPS) and the Brief Symptom Inventory (BSI) were used to collect clinical data.
Results: The DRD2 rs1800497 variant and a variable number tandem repeat (VNTR) located in exon three of DRD4 were investigated for association with PTSD. In case control analyses we did not identify any significant associations. Within the PTSD current patients, we identified an association of DRD2 rs1800497 with BSI in the genotypic and the recessive model with the T allele as the risk allele.
Conclusion: Our findings suggest that rs1800497 of DRD2 gene is involved in pathogenesis of PTSD.

Ključne riječi

PTSD; DRD2 rs1800497 variant; DRD4 VNTR Exon 3, CAPS; BSI

Hrčak ID:

235173

URI

https://hrcak.srce.hr/235173

Datum izdavanja:

9.7.2019.

Posjeta: 823 *