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SERUM BIOMARKERS OF COLLAGEN TYPE I AND TYPE III TURNOVER IN HEART FAILURE – THE NEED FOR REAPPRAISAL

ASPARUH NIKOLOV ; Radna skupina za istraživanje srčanožilnih bolesti, Zavod za znanstveno istraživanje, Medicinski fakultet u Plevenu, Pleven, Bugarska
MARIA TZEKOVA ; Sveučilišna bolnica Pleven, Druga kardiološka klinika, Odjel propedeutike u internoj medicini, Medicinski fakultet u Plevenu, Pleven, Bugarska
KONSTANTIN KOSTOV ; Sveučilišna bolnica Pleven, Druga kardiološka klinika, Odjel propedeutike u internoj medicini, Medicinski fakultet u Plevenu, Pleven, Bugarska


Puni tekst: engleski pdf 185 Kb

str. 145-152

preuzimanja: 514

citiraj


Sažetak

Cardiac extracellular matrix is a complex structure presented by a network of fi brillar collagen, fi bronectin, laminin, fi brillin, elastin, glycoproteins and proteoglycans. Myocardial fi brillar collagens (collagen type I and type III) are the main proteins responsible for the structural integrity of the bordering cardiomyocytes. Increased accumulation of fi brillar collagen leading to fi brosis has been reported in pathological cardiovascular conditions like heart failure. Amino-terminal and carboxyterminal propeptides of collagen type I and III are the two major collagen types playing a central role in this process. Derived products from their turnover have been determined in serum of patients with heart failure. Collagen type I and III propeptides refl ect collagen synthesis and degradation. Their use as biomarkers with prognostic or diagnostic aim is an area of intensive studies. This review article summarizes the actual available literature data on serum markers of collagen type I and III turnover in heart failure and discusses their potential as circulating indicators of cardiac fi brosis. The use of collagen type I and III peptides for diagnosis, prognosis and monitoring of heart failure is thoroughly discussed too.

Ključne riječi

collagen; biomarkers; heart failure; myocardial fibrosis

Hrčak ID:

244546

URI

https://hrcak.srce.hr/244546

Datum izdavanja:

6.10.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.509 *