Medicina, Vol. 56 No. 4, 2020.
Ostalo
https://doi.org/10.21860/medflum2020_245236
The development of panurothelial carcinoma after kidney transplantation in patient with endemic nephropathy
Ante Jakšić
orcid.org/0000-0001-6622-9463
; Klinika za urologiju, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Josip Španjol
; Klinika za urologiju, Klinički bolnički centar Rijeka, Rijeka, Hrvatska, Medicinski fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska
Romano Oguić
; Klinika za urologiju, Klinički bolnički centar Rijeka, Rijeka, Hrvatska, Medicinski fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska
Antun Gršković
; Klinika za urologiju, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Mauro Materljan
; Klinika za urologiju, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Monika Posavac
; Medicinski fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska
Ivan Bubić
; Medicinski fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska, Zavod za nefrologiju, dijalizu i transplantaciju bubrega, Klinika za internu medicinu, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Dean Markić
; Klinika za urologiju, Klinički bolnički centar Rijeka, Rijeka, Hrvatska, Medicinski fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska
Sažetak
Aim: Endemic nephropathy (EN) is a chronic kidney disease caused by long-lasting exposure to aristolochic acid. EN is linked to the development of end-stage renal disease but also with the development of urothelial carcinoma, especially upper urinary tract carcinoma. We present a rare case of patient with EN who developed panurothelial cancer after kidney transplantation. Case report: In a 76-year-old woman with EN, a successful kidney transplantation was performed in 2013. After the transplantation, superficial bladder cancer was diagnosed and therefore treated with transurethral resection a few times. Later on, carcinoma of the upper urinary tract was also diagnosed so the bilateral nephroureterectomy was performed. Despite modified immunosuppression and surgical treatment, the metastatic disease was developed and the patient died three years after the transplantation, with the graft still being functional. Conclusion: Patients with EN have a higher risk of developing panurothelial carcinoma. Special attention must be given to EN patients who had kidney transplantation. In this group of patients, special considerati on must be emphasized on pretransplant evaluation and follow-up after kidney transplantation.
Ključne riječi
endemic nephropathy; kidney transplantation; nephroureterectomy; renal insufficiency
Hrčak ID:
245236
URI
Datum izdavanja:
1.12.2020.
Posjeta: 1.196 *